1

Iranian Epidemiological and Genetic Breast Cancer Study

(IR-BCS)

Introduction

Hereditary Breast Cancer (HBC) is a well-characterized syndrome which predisposes individuals to a higher lifetime risk of developing breast, ovarian, or other types of cancers compare to normal population. The main cause of this syndrome has been mainly attributed to the mutations in the BRCA1, BRCA2 and less penetrant genes including PALB2 and RAD51C. As familial breast cancer needs different types of management due to future risk of developing cancers, therefore, different risk reduction and treatment strategies are needed for affected and also non-affected people who are at increased risk of developing cancer.
Cancer Research Institute, based on an international collaboration with the Women’s College Research Institute, University of Toronto (Canada), has been attempting to design a study on almost 400 patients with breast cancer to investigate the frequency of mutations in BRCA1, BRCA2, as well as PALB2 and RAD51C. In addition environmental and risk factors data of 1000 cases and healthy controls matched for age and residential place have been collected since 2012 up to 2016. The aim of this study is to find out hot spots mutations in Iranian breast cancer patients with different ethnic background and to find out possible association with specific risk factors.

Main objectives of the project:Main objectives of the project:Estimation of the prevalence of BRCA1, BRCA2, PALB2 and RAD51C gene mutations in Iranian population of breast cancer patientsSecondary objectives of the projects: A. Estimation of the prevalence of gene mutations in Iranian patients by ageB. Estimation of the prevalence of mutations in the susceptibility genes in breast cancer patients by different  ethnic groupC. To conduct a case-control study and to estimate relative risks of different  environmental risk factorsD. To conduct role of dietary factors and occurrence of breast cancer in Iranian populationE. To conduct genetic association studies and evaluate gene-environment interaction base on this setting F. Identification of hotspots gene mutations in breast cancer patients in Iran

Principle investigator in Iran:

   Dr. Kazem Zendehdel, MD, PhD
Associate professor of cancer epidemiology, Tehran University of Medical sciences
Deputy of Research, Cancer Research Center, Cancer Institute, Tehran, Iran

Co-investigators in Iran:

      Dr. Iraj Harirchi
Associate Professor of cancer surgery, Cancer Research Center, Tehran University of Medical Sciences
Deputy Minister of Health, Tehran, Iran

     Dr. Reza Shirkoohi, MD, PhD
Assistant Professor of cancer genetics, Tehran University of Medical Sciences, Cancer Research Center, Cancer Institute, Tehran, Iran
Junior investigators in Iran

     Elmira Ebrahimi

     Reza ghiasvand

Principle investigator in Canada:

     Prof. Steven Narod, MD, FRCPC, FRSC
Senior Scientist, Women’s College Research Institute
Director, Familial Breast Cancer Research Unit, Women’s College Research Institute
Professor, Dalla Lana School of Public Health, University of Toronto
Professor, Department of Medicine, University of Toronto
Tier 1 Canada Research Chair in Breast Cancer

     Dr. Mohammad Reza Akbari, MD, PhD
Scientist, Women’s College Research Institute
Assistant Professor, Dalla Lana School of Public Health, University of Toronto

Research assistant

Data Collection Team
Vahideh Peyghamabari

Maryam Mousavi

Mohammad Golmahi

Epidemiology and Biostatistics Team

Farzad Maleki

Ali Rafei

Nutrition Team

Fatemeh Tourang

Bahereh Sasanfar

Booyani

Valsalami